First Call

closed

EASI-Genomics invites external users to apply for Transnational Access by opening this First Call for proposals. Interested users can submit proposals via this website, by connecting to the ARIA online submission platform (online platform will be available by April 5th).

The support offered by Transnational Access comprises wet-lab and/or large-scale genomics data analysis. Of note, EASI-Genomics can also provide data analysis for already existing data sets. In this case, applicants should describe available data including sequencing technology used to generate it and the objective of the analysis. Costs of external user projects for consumables and for personnel required at the facilities will be covered by EASI-Genomics.

The First Call for proposals will be open until April 25, 2019, 20:00 CET. Eligible proposals will be evaluated for scientific quality, feasibility and impact. Proposals will be handled confidentially. Read more about the submission and selection process here.

EASI-Genomics recommends external users to contact the facilities offering the services of interest in order to discuss the feasibility of the submitted project prior to the submission of proposal.

Topics of the 1st Call for proposal:

  1. Sequencing of ancient DNA. EASI-Genomics offers to sequence ancient DNA at its state-of-the-art equipped facilities. Applicants need to provide a detailed description of the objectives of their project, available sample materials, and explain wet-lab and/or computational procedures required for the execution of the project.
  2. Microbiome analyses of population-based and disease cohorts. The EASI-Genomics Infrastructure solicits project proposals in microbiome analysis. Proposals should focus on the human microbiome in relation to human disease. Applicants need to explain the scientific value and quality control of the sample cohort(s). Wet-lab and/or computational procedures required for support should be specified.
  3. Single-cell genomics. EASI-Genomics will support projects in single-cell analysis. Techniques such as sc-3´tag RNA sequencing, sc-full length transcript sequencing, sc-ATAC-sequencing, sc-DNA methylation sequencing and in situ RNA sequencing are available. Applicants need to describe the objective of the research proposed, what samples are available and within what timeframe. Procedures required for wet lab and/or for data analysis support need to be clearly outlined.
  4. Identification of epigenetic signatures in human disease. EASI-Genomics will support studies relating epigenetic features to disease. Studies with samples derived from blood or analysing surrogate epigenetic markers are excluded. Studies should focus on specific tissues/cell types to decipher epigenetic signatures with mechanistic relevance to disease. Applicants must specify available samples. Procedures required for wet lab and/or for data analysis support should be detailed.
  5. DNA and chromatin alterations. Projects should focus on mechanistically studying DNA and chromatin architecture alterations relevant to disease. For example, this can include analysis of the effect of structural variation or other functional analyses. Applicants need to describe the relevance of available sample materials for disease-relevant and mechanistic analyses. Applicants should specify wet-lab and/or computational procedures required for support.
  6. De novo sequence assembly and annotation projects of species of ecological and economic relevance. The EASI-Genomics Infrastructure will support integrated projects in de novo assembly and annotation of ecologically and/economically relevant species. Applicants need to describe available samples including their economical and/or ecological relevance. Procedures available at EASI-Genomics laboratories for these projects are Illumina short-read DNA and RNA sequencing and Oxford Nanopore long-read DNA and RNA sequencing in the wet lab and state-of-the-art data analysis support for de novo genome assembly and annotation.

Timeline:

Call open: 25.03.2019 8:00 CET

Proposal submission deadlines: 25.04.2019 20:00 CET

Notification to applicants: by 12.07.2019

Start of projects: latest 6 months after notification

Start date:
Mar-24-2019 08:00h
Closing date:
Apr-25-2019 20:00h

Services included

ATAC Seq

Assay for Transposase Accessible Chromatin with high-throughput sequencing

Hi-C Seq

Genome-wide Chromatin Conformation Capture method using proximity ligation

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