Access in a nutshell
EASI-Genomics will provide free-of-charge sequencing and data analysis services to selected projects. Researchers from academia or industry willing to benefit from this opportunity will have to submit complete proposals responding to the EASI-Genomics Calls, through the online application platform established for this purpose. Eligible proposals will be evaluated by external reviewers, and eventually selected and allocated to one of the EASI-Genomics facilities. The sections below summarize the application, selection, and implementation processes.
Access: EASI-Genomics provides Transnational Access through its 11 Infrastructure nodes/facilities. The support offered comprises sample processing, sequencing and/or large-scale genomics data analysis. EASI-Genomics will support between 150 and 300 access projects for a total budget of 6 million € over the next 4 years.
Providers: Eleven infrastructure nodes or facilities will be providing sequencing and/or bioinformatic analyses services. More information about EASI-Genomics facilities can be found here.
Services provided: EASI-Genomics offer is focused on advanced sequencing and data analysis services. The list of services offered by EASI-Genomics can be found here.
Timeline: EASI-Genomics will launch four calls over a period of 4 years. EASI-Genomics Transnational and Extraordinary Access Calls will be announced and published on EASI-Genomics website and on its Twitter account (@EasiGenomics). The opening and closing date and time of each call as well as the topics and services offered for each call will be published online on this page.
- Applicants will be able to submit their proposal through an online application platform on the website for a period of 6 weeks.
- Applicants will be notified about acceptance/rejection of their proposal within 8 to 10 weeks.
- The selected users will have to sign a Memorandum of Understanding no later than 3 months after notification of the project's selection.
- Samples and/or data will have to reach the EASI-Genomics providers within 6 months of the notification of the project's selection.
Online application system: The ARIA application platform for EASI-Genomics Access Calls is handled by Instruct-ERIC. Although potential EASI-Genomics users are requested to register with the ARIA system, the application, review and reporting process will be handled by EASI-Genomics.
Open science policy: Data resulting from EASI-Genomics access should be published by the user. Open access (gold or green) is required for any publication of access results. Costs of open-access publication should be covered by the user.
An exception may be considered for SMEs accessing EASI-Genomics services, which are encouraged but not obligated to disseminate the access project results.
Sequencing data generated with EASI-Genomics facility(ies) have to be deposited to the open access repositories legally set up and maintained by the EBI and CNAG-CRG, namely the ENA and EGA databases for open and controlled access respectively, no later than publication time.
Funding statement: EASI-Genomics funding must be clearly acknowledged in all publications by: “EASI-Genomics - This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 824110”.
• Applicants may come from academia or industry (including SMEs).
• Applicants may have their home institutions based in the EU Member States or Associated Countries as defined by the Horizon 2020 programme, or outside of the EU.
• Access is transnational only, applicants cannot request access to services only offered by facility(ies) from their home country.
• EASI-Genomics principal investigators and members of their research groups are not eligible to apply.
• Applicants are required to provide copies of valid legal and ethical authorisations relative to their research, their samples and/or their data through the ARIA submission platform online at the time of submission of their application.
• Applicants agree with the data sharing and publication policy of EASI-Genomics.
• Applicants whose proposal was selected for funding in a previous EASI-Genomics call for TNA are not allowed to apply to a next call until sequencing and bioinformatics analysis of their funded project has been completed.
• Applicants or co-applicants whose proposal was not selected for funding in a previous EASI-Genomics call for TNA are allowed to apply again.
• For a given EASI-Genomics TNA call, the number of applications that can be submitted as the main applicant is limited to 1 per research group.
• Applicants will be asked to provide a rationale and justify the management of sex and/or gender, ethnicity and diversity aspects in their research design. They will be asked to state the potential limitations of their study regarding these specific dimensions.
Applicants are encouraged to get in contact with the potential provider facilities before submission of their proposal to discuss the feasibility and technical specificities of their project through the generic email address provided at each facility page.
Applicants are instructed to avoid referring to a specific EASI-Genomics facility in their proposal.
Applicants are invited to submit their proposal through an online application system, the ARIA application platform for EASI-Genomics Transnational Access Calls. ARIA is handled by Instruct-ERIC and is accessible from EASI-Genomics website at the open call page and directly using this link.
Applicants are required to register upon their first visit to ARIA or log in directly if they have previously registered onto ARIA platform.
Once registered, the applicants are required to follow ARIA instructions.
A note on Information to Data Subjects relative to the processing and management of user’s personal data through the reviewing process can be found here.
Only biological samples of biosafety containment level (BSL) 1 can be shipped to EASI-Genomics facilities. Proposal for projects requiring handling of samples of category BSL-2 or BSL-3 cannot be accepted.
Proposals for projects involving sequencing of material from human embryonic stem cells or tissue of human embryonic origin cannot be accepted.
Proposals for projects involving complex process for DNA extraction and integrative bioinformatics analysis in the framework of scientific collaboration will be privileged.
EASI-Genomics applications will go through three stages of review. The application will remain strictly confidential throughout the review process.
Stage 1: eligibility check: The first stage will be an eligibility check. (cf. above)
Stage 2: external reviewers and feasibility check: The second evaluation stage is an independent scientific review, conducted by two external reviewers. Proposals will be assessed based on the following detailed criteria:
- Scientific merit of the proposal;
- Impact and innovation potential;
- Availability of biological samples and data;
- Quality of phenotypic data;
- Dissemination of results in open access media and data management plan. (SMEs may be released from this criterion in case of documented conflicting reasons).
In addition to the external experts, one internal EASI-Genomics member will contribute by reviewing the technical feasibility of each project. The call managers will generate a ranked list of the applications that could benefit from access.
Stage 3: decision and allocation (Access Committee): Access Committee of EASI-Genomics, consisting of representatives of the infrastructure sites and one Scientific Advisory Board member, will establish a threshold score for successful project proposals.
The successful projects will be allocated by the committee to the most appropriate EASI-Genomics sites according to the strengths of specific methodology and various expertise of the facility, always considering the trans-nationality requirement.
Applicants will be informed about the decision within 10 –12 weeks after the end of the submission period.
- Applicants of non-selected proposals will be informed by email about the result of the selection process, including the provision of reasons for non-acceptance.
- Successful applicants will be informed by email about the results of the evaluation and the assignment of the project to an EASI-Genomics facility.
Selected project proposals, in particular those dealing with human samples and attached data, will be further evaluated for compliance with ethical standards and laws by EASI-Genomics ELSI experts.
No later than 3 months after notification of proposal acceptance and EASI-Genomics facility allocation, successful applicants are expected to sign a Memorandum of Understanding regulating the interactions between EASI-Genomics and the users. Both users and the allocated EASI-Genomics facility(ies) will be responsible for establishing a Material and/or Data Transfer Agreement (MDA or DTA) directly among themselves.
Applicants are responsible to provide the allocated EASI-Genomics facility(ies) with biological samples and/or data described in the proposal within 6 months of notification of proposal acceptance and EASI-Genomics facility allocation.